Tuberculosis

Pathophysiology

These following images illustrate gross pathologic findings with tuberculosis:

ghon complex in lung,gross.

Note the subpleural granuloma at the right along with the granuloma in the hilar lymph node, typical findings for the Ghon complex of primary TB.

Ghon complex in lung,closer view,gross.

On closer inspection,caseous tan necrotic tissue is seen to constitute the granulomas in this gross appearance of a Ghon complex. Most patients with primary TB are asymptomatic, and the granulomas resolve.

Cavitary tuberculosis in lung,gross.

Extensive cavitation of multiple granulomas of lung are typical for secondary TB from reactivation of primary infection or reinfection as an adult. Such lesions have a prediliction for appearance in the upper lobes of the lung.

Cavitary tuberculosis in lung, closer view,gross.

The caseous necrosis is extensive, and cavitation is prominent. Such patients can be highly contagious.

Cavitary tuberculosis in lung, florid, gross.

Another example of florid cavitation in secondary tuberculosis is shown here.

Miliary tuberculosis in lung, gross.

The small millet seed sized granulomas in this lung are typical for miliary Tuberculosis.

Miliary tuberculosis in lung, closer view,gross.

Miliary tuberculosis, as seen here, typically occurs when resistance to mycobacterial infection is poor.